Cefixime 100,200 mg
Cefixime is a semisynthetic, cephalosporin antibiotic for oral administration.
As with other cephalosporins, bactericidal action of cefixime results from inhibition of cell- wall synthesis.
Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to
penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime.
Cefixime exhibits good invitro activity with MIC90 <1mg/I, against most of the enterobacteriaceae, haemophilus influenzae and neisseria gonorrhoea (including b-Iactimase producing strains), beta haemolytic streptococci of groups A and B streptococcus pneumoniae. However staphylococcus aureig is considerably less susceptible and faecal streptococci, pseudomonas aeroginosa, most anaerobes and chlamydia trachomatis are insusceptible. Against enterobacteriaceae, it's activity is normally superior to that of amoxicillin, cefaclor, and cephalexin, but inferior to that of ciprofloxacin. It is more active than than co- trimoxazole against certain species (providencia stuartii, proteus vulgaris and klebsiella spp) but less active against escherichia coli, enterobacter cloacae and enterobacter aerogenes against H .influenza and N .gonorrhoea
Cefixime is indicated in the treatment of the following infections :
-> Typhoid fever
-> Uncomplicated Urinary Tract Infections
-> Otitis Media
-> Pharyngitis and Tonsillitis
-> Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis
-> Uncomplicated gonorrhea
DOSAGE AND ADMINISTRATION
The recommended dose of Cefixime is 400 mg daily. This may be given as 400 mg once daily or as 200 mg
every 12 hours. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose
of 400 mg is recommended.
The recommended dose is 8 mg/kg/day of the suspension. This may be administered as a single daily dose or
may be given in two divided doses, as 4 mg/kg every 12 hours. In Typhoid the dose is 20 mg/kg/ day in two
divided doses or as a single dose In the treatment of infections due to S. pyogenes, a therapeutic dosage of
Cefixime should be administered for at least 10 days.