Azithromycin 250mg Tabs.
Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin acts by binding to the 50S
ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis.
Oziset is indicated in the treatment of:
->Upper respiratory tract infections (including ear, nose and throat infections): Tonsillitis, sinusitis, otitis
media and pharyngitis.
-> Lower respiratory tract infections: Community acquired pneumonias, acute bacterial exacerbations of
chronic bronchitis, chronic obstructive pulmonary disease, bronchitis due to Haemophilus influenzae,
Moraxella catarrhalis or Streptococcus pneumoniae.
-> Genitourinary tract infections (including sexually transmitted diseases): Urethritis, prostatitis, cervicitis,
cervico-vaginitis and salpingitis due to N. gonorrhoeae and C. trachomatis. Genital ulcer disease
(chanchroid) in men due to Haemophilus ducreyi.
-> Skin and skin structure infections: Folliculitis, furuncles, carbuncles, impetigo, pyoderma, infected ulcer,
infected dermatitis, cellulitis and erysipelas due to S. aureus, S. pyogenes or S. agalactiae.
-> Prophylaxis and treatment of malaria.
-> Treatment of acne.
-> Treatment of chlamydial conjunctivitis.
DOSAGE AND ADMINISTRATION
500 mg as a single dose on the first day followed by 250 mg once daily on days 2 to 5 for a total dose of 1.5 gm
or 500 mg once daily for 3 days.
Sexually transmitted diseases: Gonorrhoea: 2 gm as a stat dose Chancroid: 1 gm as a stat dose Non-
gonococcal urethritis and cervicitis due to C. trachomatis —1 gm as a stat dose Syphilis: 1 gm o.d. for 5 days or
500 mg o.d. for 10 days.
500 mg on first day followed by 250 mg/day for 7 days. Treatment: 1000-1500 mg once daily for 3 days with usual doses of chloroquine.
250-500 mg on 3 consecutive days in a week for 12 weeks.
Children under 16 years
The usual dose for children is 10 mg/kg body weight orally, once a day for 3 days. Alternatively after a 10
mg/kg body weight oral loading dose on the first day, therapy can be continued at a dose of 5 mg/kg body
weight on subsequent four days.
ronchitis t CAP — Community acquired pneumonia t UTIs — Urinary tract infections § SSSIs — Skin and
skin structure infections tt MDR-TB — Multi-drug resistant tuberculosis