NAXIGAB PM CAP

NAXIGAB-PM Capsules
Pregabalin 75 mg + Methylcobalamin 750 mcg

PREGABALIN — Reduces hyperalgesia and allodynia
->Increases levels of GABA by inhibiting GABA aminotransferase
->Blocks a 2 d subunits of voltage dependent calcium channels.
->Blocks NMDA receptor and glutamate release.

GABAPENTIN

Gabapentin was originally approved in the U.S. by the Food and Drug Administration (FDA) in 1994 for
use as an adjunctive medication to control partial seizures (effective when added to other antiseizure
drugs). In 2002, an indication was added for treating postherpetic neuralgia (neuropathic pain following
shingles), other painful neuropathies, and nerve related pain.

METHYLCOBALAMIN — Enhances Motor and sensory functions of neurons

-> Improves axonal regeneration
-> Increases myelination of neurons by stimulating lecithin synthesis
-> Protects nerve cells from glutamate
-> Improves nerve function

INDICATIONS:

-> Diabetic Peripheral Neuropathy Post Herpetic Neuralgia Post Traumatic Neuralgia Trigeminal Neuralgia
-> Low Back Pain

DOSAGE AND ADMINISTRATION:

->Initiate therapy with 1tab at bed time.
->Dose can be titrated to 1 tab. thrice daily as tolerated and as needed for maximum pain relief.
->Naxigab-PM dose if altered then should be done gradually over minimum 1 week period.

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