Pregabalin 75 mg + Nortryptiline 10 mg
PREGABALIN — Reduces hyperalgesia and allodynia
-> Increases levels of GABA by inhibiting GABA aminotransferase.
-> Blocks a 2 d subunits of voltage dependent calcium channels.
-> Blocks NMDA receptor and glutamate release.
1.) Diabetic Peripheral Neuropathy Post Herpetic Neuralgia Post Traumatic Neuralgia Trigeminal Neuralgia
2.) Low Back Pain
DOSAGE AND ADMINISTRATION:
1.) Initiate therapy with 1tab at bed time.
2.) Dose can be titrated to 1 tab. thrice daily as tolerated and as needed for maximum pain relief.
3.) Naxigab-PM dose if altered then should be done gradually over minimum 1 week period.