CEDOBACT DOUBLE STRENGTH
Cefpodoxime Proxetil 100 mg
ADVANTAGE OF CEFPODOXIME + CLAVULANICACID COMBINATION
Cefpodoxime is a 3rd generation cephalosporin active against many gram positive and gram negative
organisms and is beta lactamase stable. It exhibits excellent activity against Streptococcus pneumoniae,
methicillin susceptible Staphylococci, Haemophilus influenzae, Moxaxella catarrhalis and Nesseria spp which
are the most common community acquired and hospital acquired infections.
However in recent past it observed that due to production of Beta lactamase enzyme MIC values of
cefpodooxime has increased for certain micro-organism. As a result, cefpodoxime may be less effective in
Protective role of Clavulanic acid:
Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus.
Clavulanic acid binds to and inactivates them thus preventing the destruction of cefpodoxime that is a substrate
for this enzyme.
It has poor intrinsic antimicrobial activity , but it is a ‘suicide’ inhibitor (irreversible binder) of 13- lactamases
produced by a wide range of gram positive and gram negative microorganism. Clavulanic acid is well
absorbed by mouth.
The combination of Cefpodoxime (3rd generation cephalosporin) and Clavulanic acid (beta-lactamase
inhibitor) provides a solution for treatment of bacterial infections caused by beta lactam resistant pathogens.