Amoxycillin 500/200 mg + Clavulanic Acid 125/28.5 mg
Autoclav is a formulation of amoxycillin and clavulanic acid. Amoxycillin has a broad spectrum of bactericidal
activity against many gram-positive and gram-negative microorganisms.
Amoxycillin is, however, susceptible to degradation by (beta)-lactamases, and therefore, the spectrum of
activity does not include organisms which produce these enzymes.
Clavulanic acid is a (beta)-lactam, structurally related to the penicillins, which possesses the ability to
inactivate a wide range of (beta)-lactamase enzymes commonly found in microorganisms resistant to
penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid-
mediated (beta)-lactamases frequently responsible for transferred drug resistance.
RATIONALE OF COMBINATION The formulation of amoxycillin and clavulanic acid in Autoclav protects
amoxycillin from degradation by (beta)-lactamase enzymes and effectively extends the antibiotic spectrum
of amoxycillin to include many bacteria normally resistant to amoxycillin and other (beta)-Iactam antibiotics.
Thus, Autoclav possesses the properties of a broad-spectrum antibiotic and a (beta)-lactamase inhibitor.