Amoxycillin 500/200 mg + Clavulanic Acid 125/28.5 mg
Autoclav is a formulation of amoxycillin and clavulanic acid. Amoxycillin has a broad spectrum of bactericidal
activity against many gram-positive and gram-negative microorganisms.
Amoxycillin is, however, susceptible to degradation by (beta)-lactamases, and therefore, the spectrum of
activity does not include organisms which produce these enzymes.
Clavulanic acid is a (beta)-lactam, structurally related to the penicillins, which possesses the ability to
inactivate a wide range of (beta)-lactamase enzymes commonly found in microorganisms resistant to
penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid-
mediated (beta)-lactamases frequently responsible for transferred drug resistance.
RATIONALE OF COMBINATION The formulation of amoxycillin and clavulanic acid in Autoclav protects
amoxycillin from degradation by (beta)-lactamase enzymes and effectively extends the antibiotic spectrum
of amoxycillin to include many bacteria normally resistant to amoxycillin and other (beta)-Iactam antibiotics.
Thus, Autoclav possesses the properties of a broad-spectrum antibiotic and a (beta)-lactamase inhibitor.
CLAVULANIC ACID ADVANTAGE:
Retains the activity of amoxicillin against Streptococci including pneumococci
Restores the activity against beta lactamase producing staphylococci, E.coli ,H. influenzae & M. Catarrhalis
Extends its activity against Klebsiella spp. & Bacteroides fragilis (which have intrinsic b eta-lactamase
Autobact is indicated in the treatment of infections caused by susceptible strains of the designated
organisms in the conditions listed below:
Lower Respiratory Tract Infections – caused by (beta)-lactamase producing strains of H. influenzae and M.
Otitis Media – caused by (beta)-lactamase producing strains of H. influenzae and M. catarrhalis.
Sinusitis – caused by (beta)-Iactamase producing strains of H. influenzae and M. catarrhalis.
Skin and Skin Structure Infections – caused by (beta)-lactamase producing strains of S. aureus, E. coli and
Urinary Tract Infections – caused by (beta)-lactamase producing strains of E. coli, Klebsiella spp. and Enterobacter-spp.
DOSAGE AND ADMINISTRATION
Autobact Dry Syrup
->Usual dosages for the treatment of infection.
->Patients aged 12 weeks (3 months) and older.
USPS OF AUTOBACT TABLETS:
1.) Spectrum of activity against anaerobes and gram negative pathogens
2.) Drug of Choice in Adults with pneumonia, bronchitis as well as URTIs, SSTIs, UTIs
3.) Category B drug
4.) Safe and well tolerated especially in infants and pregnant mothers
5.) Safe during lactation
USPS OF AUTOBACT DRY SYRUP:
1.) THE MOST PALATABLE AND DELICIOUS SYRUP
2.) 100% compliance
3.) 100% efficacy in otitis media
4.) Ensures 95% bacteriological eradication rate
5.) Preferred antibiotic in pediatric…considered as gold standard